List of publications


· Tobias Bock, Eric W. Buss, Olivia M. Lofaro, Félix Leroy, Bina Santoro, Steven A. Siegelbaum.  The HCN1 hyperpolarization-activated cyclic nucleotide-gated channel enhances evoked GABA release from parvalbumin positive interneurons. BioRxiv 2022.11.11.516205; doi: 10.1101/2022.11.11.516205

· Arun Asok, Félix Leroy, Cameron Parro, Christopher A. de Solis, Lenzie Ford, Michelle N. Fitzpatrick, Abigail Kalmbach, Rachael Neve, Joseph B Rayman, Eric R. Kandel. A multisensory circuit for gating intense aversive experiences. BioRxiv 2021.05.01.441648; doi: 10.1101/2021.05.01.441648

Peer-reviewed publications


· Noelia Sofia de León Reyes, Paula Sierra Díaz, Ramon Nogueira, Antonia Ruiz-Pino, Yuki Nomura, Christopher de Solis, Jay Schulkin, Arun Asok, Félix Leroy. Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice. Cell 2023. doi:10.1016/j.cell.2023.08.010


· Merseburg A, Kasemir J, Buss EW, Leroy F, Bock T, Porro A, Barnett A, Tröder SE, Engeland B, Stockebrand M. Moroni A, Siegelbaum SA, Isbrandt D, Santoro B. Seizures, behavioral deficits and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy. eLife (2022) 11:e70826.

· Besnard A, Leroy F. Top-down regulation of motivated behaviors via lateral septum sub-circuits. Perpective article in Molecular Psychiatry 2022. doi:10.1038/s41380-022-01599-3. PMID: 35581296

· Lopez-Rojas J, de Solis CA, Leroy F, Kandel ER, Siegelbaum SA. A direct lateral entorhinal cortex to hippocampal CA2 circuit conveys social information required for social memory. Neuron 2022 May 4;110(9):1559-1572.e4. PMID: 35180391


· Leroy F, de Solis CA, Boyle LM, Bock Tobias, Lofaro OM, Buss EW, Asok A, Kandel ER, Siegelbaum SA. Enkephalin release from VIP interneurons in the hippocampal CA2/3a region mediates heterosynaptic plasticity and social memory. Molecular Psychiatry 2021, doi: 10.1038/s41380-021-01124-y. PMID: 33990774


· Oliva A, Fernández-Ruiz A, Leroy F, Siegelbaum SA. Hippocampal CA2 sharp-wave ripples reactivate and promote social memory. Nature 2020 Nov;587(7833):264-269. PMID: 32968277


· Asok A, Leroy F, Rayman J and Kandel ER. Molecular Mechanisms of the Memory Trace. Trends in Neuroscience. 2019 Jan;42(1):14-22. doi: 10.1016/j.tins.2018.10.005. PMID:30391015


· Leroy F, Park J, Asok A, Brann DH, Meira T, Boyle LM, Buss EW, Kandel ER and Siegelbaum SA. A circuit from hippocampal CA2 to lateral septum disinhibits social aggression. Nature. 2018 Dec 5; 564(7735):213-218. PMID: 30518859.

· Meira T, Leroy F, Buss EW, Park J and Siegelbaum SA. A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics. Nature Communication. 2018 Oct 9; 9(1):4163. PMID: 30301899

· Elgueta C, Leroy F, Vielma AH, Schmachtenberg O, Palacios AG. Electrical coupling between A17 cells enhances reciprocal inhibitory feedback to rod bipolar cells. Science Report. 2018 Feb 15; 8(1):3123. PMID: 29449585.


· Clark A, Leroy F, Martyniuk K, Feng W, McManus E, Bailey M, Javitch J, Balsam P and Kellendonk C. Dopamine D2 receptors in the paraventricular thalamus attenuate cocaine locomotor sensitization. eNeuro. 2017 Oct 17; 24; 4(5). PMID: 29071300.

· Leroy F, Brann DH, Meira T and Siegelbaum SA. Input-timing dependent plasticity in the hippocampal CA2 region and its potential role in social memory. Neuron. 2017 Aug 30; 95(5):1089-1102.e5. PMID: 28823730.


· Leroy F, Lamotte d’Incamps B. The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation. Journal of Visual Experiments. 2016 Oct 13; (116). PMID:27768090.


· Leroy F, Lamotte d’Incamps B and Zytnicki D. Potassium currents dynamically set the recruitment and firing properties of F-type motoneurons in neonatal mice. Journal of Neurophysiology. 2015 Sep; 114(3):1963-73. PMID: 26269551.

· Leroy F and Zytnicki D. Is hyperexcitability really guilty in amyotrophic lateral sclerosis? Neural Regeneration Research. 2015 Sep; 10(9):1413-5. PMID: 26604899.


· Leroy F, Lamotte d’Incamps B, Imhoff-Manuel R and Zytnicki D. Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis. eLife 2014 Oct 14; (3). PMID: 25313866.


· Branchu J, Biondi O, Chali F, Collin T, Leroy F, Mamchaoui K, Makoukji J, Pariset C, Lopes P, Massaad C, Chanoine C, Charbonnier F. Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor-neuron expression in spinal-muscular-atrophy-like mice and patient cells. J. Neurosci. 2013 Mar 6; 33(10):4280-94. PMID:23467345.


· Bouthour W*, Leroy F*, Emmanuelli C, Carnaud M, Dahan M, Poncer J.C and Lévi S. A human mutation in Gabrg2 associated with generalized epilepsy alters the membrane dynamics of GABAA receptors. Cerebral Cortex. 2012 Jul; 22(7):1542-53. PMID: 21908847 (*co-first authors).


· Nishijima T, Piriz J, Duflot S, Fernandez A.M, Gaitan G, Gomez-Pinedo U, Garcia Verdugo J.M, Leroy F, Soya H, Nuñez A and Torres-Aleman I. Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS. Neuron 2010 Sep 9; 67(5):834-46 PMID: 20826314.


· Manuel M, Iglesias C, Donnet M, Leroy F, Heckman CJ, Zytnicki D. Fast kinetics, high-frequency oscillations, and subprimary firing range in adult mouse spinal motoneurons. Journal of Neuroscience. 2009 Sep 9; 29(36):11246-56. PMID: 19741131.